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What to Expect from a Colonoscopy and Colorectal Screening

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BY: Armen Gregorian, MD | December 13, 2025 | Colonoscopy & Colorectal Screening


A colonoscopy is a common test that lets a doctor look inside the large intestine (colon) with a small camera. It is used to check symptoms like bleeding, and it is also used for colorectal cancer screening.Most people worry about pain, the prep, or “what happens if they find something.” The truth is that the prep is usually the hardest part, the procedure itself is often done with sedation, and many findings can be handled right then.This guide walks through what to expect before, during, and after a colonoscopy in Glendale, CA. It also clears up a few misconceptions that make the experience feel scarier than it needs to be.

Why People Struggle

  • They underestimate the bowel prep and end up not fully cleaned out, which can mean a longer exam or a repeat test.
  • Medication questions get missed, especially blood thinners, diabetes meds, and supplements.
  • They expect the procedure to be painful, without realizing sedation is commonly used for colonoscopy.
  • They do not plan the day around recovery, like arranging a ride home and taking the rest of the day off.
  • They are not sure what “polyps” are, or what it means if one is removed during the exam.

Colorectal cancer is not just an older adult issue anymore and more people are being diagnosed at younger ages than many expect. For a clear explanation of why starting sooner can matter read early screening for colorectal cancer.

In this article, you’ll learn how to avoid these pitfalls and make informed choices.

Before the Colonoscopy: Prep, Diet, and Planning

The goal of colonoscopy prep is simple: clear the colon so the doctor can see well. If stool is left behind, small polyps can be harder to spot, and the test may not be as useful.

Your care team will give you specific instructions. In general, people are asked to follow a short-term diet change, then use a bowel-cleansing laxative plan, and to talk with the doctor about all medicines and supplements they take. It is also standard to plan a ride home, since you may not be allowed to drive after sedation.

Regular screening is the best way to catch colon cancer early and remove polyps before they become a problem so if you are on the fence it helps to understand why doctors push screening so strongly. Read our guide on importance of regular screenings for colon cancer to see how early detection works and who should consider getting screened sooner.

One small tip that matters more than people expect: follow the timing exactly, not “close enough.” The schedule is designed so the colon is clear at the time of the exam, not just the night before.

During the Procedure: What Happens in the Room

A common mistake is thinking the colonoscopy is like a dental visit where you grit your teeth through it. That expectation can make people anxious, and anxiety can make everything feel harder.

If anxiety is the main thing holding you back you are not alone and those feelings are extremely common. Our article on emotional barriers to screening explains why fear shows up and how support and clear information can make the process feel much more manageable.

In real life, sedation or anesthesia is usually used during colonoscopy, and many patients remember little or nothing about the exam itself. A flexible tube with a camera is used to examine the colon. If the doctor sees polyps, they may be removed during the procedure, which is one reason colonoscopy can help prevent colorectal cancer over time.

If you want a broader overview of why screening matters and which tests are available, read our guide on colorectal cancer screening options. It breaks down colonoscopy, FIT, and other screening choices so you can understand what may fit your age and risk factors best.

A more effective approach is to focus on what you can control: ask how sedation is handled at that facility, be upfront about past reactions to anesthesia, and arrive with a clear list of medications and allergies.

After the Colonoscopy: Recovery, Results, and When to Call

Right after the exam, you will spend a short time in recovery while the sedation wears off. Many people feel groggy, and mild cramping or gas can happen because air is used during the procedure.

Your doctor will usually discuss what was seen and whether anything was removed. If biopsies were taken or polyps were removed, final lab results often come later.

Complications are uncommon, but they can happen. Contact your care team right away if you have severe belly pain, ongoing heavy bleeding, fever, or symptoms that feel quickly worse instead of better.

FAQs

Is a colonoscopy painful?

Many people do not feel pain during the exam because sedation is commonly used. You may have mild cramping or gas afterward.

How long does recovery take?

Most people go home the same day, but you should plan to rest for the remainder of the day. Do not drive or make big decisions until the sedation fully wears off.

What if a polyp is found?

Polyps are common, and many can be removed during the colonoscopy. Removing certain polyps can lower colorectal cancer risk over time.

For help with what to expect from a colonoscopy in Glendale, CA, contact Armen Gregorian, MD at (818) 847-7067.

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